Association of single nucleotide polymorphism (SNP) in micro RNA-122 with genetic predisposition and early recurrence after resection for hepatocellular carcinoma / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
; (12): 786-789, 2014.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-466271
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the association of single nucleotide polymorphism (SNP) in micro RNA-122 (miRNA-122) with genetic predisposition and early recurrence after resection for hepatocellular carcinoma(HCC).Methods This is a case-control study involving 173 HCC patients.DNA were exacted from cancer tissues embedded in paraffin and were amplified by PCR.The study aimed to explore SNP in gene sequence of miRNA-122 (357 base pair including extron.The outcomes of genetic predisposition were analyzed with early recurrence after resection for HCC.Results Only rs17669 was found in miRNA-122.The genetype frequence of C/C,T/T and C/T at rs17669 gene locus were 7(4.0%),110(63.6%)and 56(32.4%),respectively.When compared to T/T genetype,C/C genetype was a protective factor of risk of HCC (OR =0.213,95% CI0.062-0.732).Genetypes had no relationship with early recurrence after resection.Conclusion For HCC recurrence,rs17669 may be associated with genetic predisposition of HCC in Hans in Jiangxi infected with HBV.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Idioma:
Chinês
Revista:
Chinese Journal of Hepatobiliary Surgery
Ano de publicação:
2014
Tipo de documento:
Artigo