Effect of combination of valsartan and alprostadil on diabetic nephropathy: A meta-analysis / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
; (12): 408-412, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-468522
Biblioteca responsável:
WPRO
ABSTRACT
The randomized controlled trials (RCTs) of treating diabetic nephropathy (DN) with alprostadil and valsartan were collected from CNKI,Wan fang date,VIP,PubMed,Embase,and Cochrane Library.The selected data was analyzed with RevMan 5.1 software.The effect of combination of valsartan and alprostadil in treating DN was evaluated.In 19 RCTs,675 cases were co-treated with alprostadil and valsartan and 670 were treated with valsartan.The results indicated that 24 h urine microalbumin excretion [WMD =-53.23,95% CI (-67.55,-38.91),P<0.01] and24 h urine protein[WMD=-0.38,95% CI(-0.69,-0.07),P=0.02] in patients treated with combination of valsartan and alprostadil were reduced more markedly than in those treated with valsartan alone.There was no significant difference in blood urea nitrogen [WMD =-0.791,95 % CI (-20.62,4.79),P =0.22] and serum creatinine[WMD=-5.82,95% CI(-19.22,7.58),P=0.39] between two kinds of treatment.These results suggest that combined treatment with valsartan and alprostadil shows advantageous effect on reducing urinary protein in DN.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Ensaio clínico controlado
/
Revisão sistemática
Idioma:
Chinês
Revista:
Chinese Journal of Endocrinology and Metabolism
Ano de publicação:
2015
Tipo de documento:
Artigo