Comparison of effects of misoprostol and carboprost methylate suppository in the painless abortion of pregnancy / 中国基层医药

ABSTRACT

Objective To compare the effects of misoprostol and carboprost methylate suppository in painless artificial abortion.Methods 164 early pregnant women who were voluntary termination of pregnancy row painless surgery and no surgery contraindications were randomly divided into the control group and the observation group,82 cases in each group.The observation group was given misoprostol 400μg in vaginal vault 1 h before surgery.Intravenous injection fentanyl 50μg,continuous intravenous injection propofol 2.0mg/kg,stopping the treatment when eyelash reflex disappeared,if necessary,additionally given propofol 0.5mg/kg.The control group was given carboprost methylate suppository(1mg) into the vaginal vault 1h before surgery,the other treatment was same as the observation group.The intraoperative BP,HR,RR,SPO2 were monitored,the cervical laxity,the total amount of propofol,operation time,recovery time,patient and surgeon satisfaction rate were recorded.Results Surgery time,recovery time,the total amount of propofol of the observation group [(3.5 ± 1.2) min,(1.9 ± 0.7) min,(105 ± 10) mg] were significantly less than the control group [(6.5 ± 1.7)min,(3.7 ± 0.6)main,(149 ± 14)mg],the relaxation of the cervix in the observation group (markedly effective in 69 cases,effective in 13 cases,ineffective in 0 case) were better than the control group (markedly effective in 52 cases,effective in 21 cases,ineffective in 9 cases).Conclusion Propofol,fentanyl compared with misoprostol combination carboprost methylate suppository had obvious cervical relaxation,significantly reducing the time dilation of the cervix,a small phenol propofol dosage,shortening the patients' recovery.time,improve the safety and satisfaction of the operation.