Expression and clinical significance of inhibitor of apoptosis protein XIAP in chiIdhood acute leukemia / 白血病·淋巴瘤

ABSTRACT

Objective To investigate the expression and clinical significance of inhibitor of apoptosis protein XIAP in childhood acute leukemia(AL).Methotis The expression of XIAP protein was detected by immunohistochemical assay in 54 children with AL.including 26 newly diagnosed and untreated AL children.23 children in remission and 5 relapsed.The eontrol included 10 children with normal bone marrow.Results The level of XIAP proteins in the bone marrow of newly diagnosed AL children was higher than that in remission and normal controls(P＜0.05),compared with that in relapsed children,with no statistical difference(P＞0.05).The level of XIAP protein in remission was higher than that in normal controls(P＜0.05).The level of XIAP protein in ALL and ANLL in newly diagnosed AL children was compared. with no statistical difference(P＞0.05).Conclusion The higher expression of XIAP may contribute to the pathogenesis and the progress of the childhood AL.