Genetic prognostic markers for acute myeloid leukemia with normal cytogenetics / 白血病·淋巴瘤

ABSTRACT

Acute myeloid leukemia (AML) is a heterogenous disorder disease, about 40 %-49 % of the adult AML and 25 % of children had normal karyotype AML, and usually categorized as an intermediaterisk group, but for acquired genetic change, such as mutations of FLT3, NPM1, CEBPα, MLL, and KIT as well as alterations in expression levels of BAALC, MN1, ERG, and EVI1, leading to significant heterogeneity for the prognosis of this group. In this report, prognostic genetic findings in normal karyotypical AML and discuss their clinical implications was reviewed.