Expression and significance of IL-17 in multiple myeloma bone disease / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 282-284, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-472626
Biblioteca responsável:
WPRO
ABSTRACT
ObjectiveTo detect IL-17 level of bone marrow in patients with multiple myeloma bone disease,and to investigate its clinical significance.MethodsThe bone marrow IL-17 levels were quantified in 33 cases of multiple myeloma patients and 20 normal control by ELISA assay. RANKL mRNA expression were detected by using RT-PCR.ResultsIn bone marrow supernatant,IL-17 was detected in both groups,and RANKL mRNA were detected in both groups too. IL-17 and RANKL mRNA levels in bone marrow of patients with MM were significantly higher than those in the control group(P<0.05). The bone marrow concentrations of IL-17 and bone marrow mononuclear cells' RANKL mRNA expression in active stage were significantly higher than those in stable stage (P<0.05).The bone marrow IL-17 and RANKL were significantly correlated (r =690,P<0.05).ConclusionIL-17 may play an important role in the pathogenesis of MM.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Leukemia & Lymphoma
Ano de publicação:
2012
Tipo de documento:
Artigo