Effects of Electroacupuncture on Expression of COX-2 in the Dorsal Horn of Spinal Cord of Arthritic Rats / 针灸推拿医学(英文版)
Journal of Acupuncture and Tuina Science
; (6): 264-266, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-472915
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
The present study was to observe the expression of COX-2 protein in the dorsal horn of the spinal cord in rats with chronic inflammatory pain to investigate whether COX-2 is involved in the mechanism of electroacupuncture (EA) analgesia.Methods:
After EA treatment, the pain score and expression of COX-2 protein in the dorsal horn of spinal cord in rats with complete Freund's adjuvant (CFA)-induced arthritis were measured by the behavioral test and immunohistochemistry technique, and compared with those of the normal group, model group and medicine group.Results:
EA could decrease the pain score significantly and repeated EA treatments had the remarkable cumulative analgesic effect; and with the increase in EA treatments, the number of COX-2 immunoreactive cells was obviously decreased.Conclusion:
EA at acupoints Yanglingquan (GB 34) and Kunlun (BL 60) had remarkable analgesic effect on adjuvant arthritis rats; and in the meantime, could inhibit the expression of COX-2 protein in the dorsal horn of spinal cord.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Journal of Acupuncture and Tuina Science
Ano de publicação:
2006
Tipo de documento:
Artigo