Research progress of microRNA in acute leukemia with molecular and cytogenetic abnormalities / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 632-635, 2014.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-474446
Biblioteca responsável:
WPRO
ABSTRACT
microRNA (miRNA) refers to small (19-25 nt) single-stranded noncoding RNA molecules that work as post-transcriptional regulator for gene expression by binding to 3' untranslated regions of target mRNA,thus inducing its digestion,degradation and translational repression.Many studies have confirmed that dysregulation of miRNA expression can cause disruption of the hematopoietic system and contribute to leukemogenesis by regulating the expression of some oncogenes and anti-oncogenes.The unique miRNA expression profiles associated with cytogenetic aberrations and mutational status of protein-coding genes may reveal insight into the biology of these leukemia types.This review discussed the latest studies on miRNA expression in different cytogenetic and molecular subtypes of acute myelocytic leukemia and acute lymphoblastic leukemia.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Leukemia & Lymphoma
Ano de publicação:
2014
Tipo de documento:
Artigo