Chromosome karyotype analysis of acute lymphocytic leukemia / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 88-90, 2013.
Article
em Zh
| WPRIM
| ID: wpr-475551
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the chromosome karyotype of acute lymphocytic leukemia (ALL) and its correlation with the clinical feature and efficacy.Methods The chromosomes of bone marrow/peripheral blood from 110 cases of patients with ALL were prepared after 24 hours culture,and G-banding were used to analyze karyotypes.Results Among 110 patients with ALL,71 cases (64.5 %) had clonal chromsomal normalities,39 cases (35.5 %) had clonal chromsomal abnormalities,24 cases (21.8 %) had chromosome structural abnormalities,11 cases (10.0 %) had chromosome number abnormalities,3 cases (2.7 %) had chromosome number and structure abnormalities,one case had chromosomal abnormalities complex karyotype.Efficacy in patients with ALL with t(9;22) (q34;q11) was worse than the other patients (Fisher s exact text,P =0.045).There was no significant difference on efficacy between in adult ALL associated with t(9;22) (q34;q11) and in children with ALL (Fisher's exact text,P =0.506).Conclusion Chromosome karyotype of ALL patients is random,chromosomal translocations such as t(9;22)(q34;q1 1) and t(4;11) (q21;q23) have poorer treatment outcomes.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Leukemia & Lymphoma
Ano de publicação:
2013
Tipo de documento:
Article