Clinical analysis on 569 cases of hand, foot and mouth diseases complicated with nerve system damages / 中国基层医药

ABSTRACT

Objective To investigate the epidemiological and clinical characteristics of hand,foot and mouth disease(HFMD) complicated with central nerve system infection,in order to improve the diagnosis and treatment.Methods Total of 569 cases of HFMD complicated with central nerve system infection were enrolled.The results of pathogen detection and CSF examination were looked into,and epidemiological and clinical characteristics were analyzed retrospectively.Results HFMD of the central nervous system infections increased year by year,endanger the children's life,pathogen detection showed positive for enterovirus type 71 (640/1077,59.4％) and coxsackie virus infection in group A (158/1077,14.7％) ; Clinical manifestationhand,foot and mouth,hips were rash (100.0％),fever(546/569,95.9.％),temperature higher than 38.5 ℃ (74.7％,425/569),there were various signs and symptoms of nervous system damage,sleepiness (187/569,32.9％),limb jitter(347/569,60.1％),easily frightened (405/569,71.2％),irritability (130/569,22.8％),convulsions (2.4％,14/569),vomiting (67/569,11.8％),choking cough (2.8 ％,16/569),irregular breathing (0.5 ％,3/569) ; Laboratory examinationthe central nervous system complications in different CFPro (P =0.992),CFWBC (P =0.994) and CRP (P =0.786),no statistical difference in such aspects of brain stem encephalitis group in CFP(P =0.001),PWBC (P =0.000) and BG (P =0.000),and the differences were statistically significant; Short-term,the combination of large dose of gamma globulin and methylprednisolone had definite efficacy.Conclusion HFMD complicated with central nervous system infections have some epidemiological and clinical characteristics,early diagnosis and treatment can reduce the incidence of severe cases and mortality.