Research advances on regulatory effect of RhoA on myocardial ischemia reperfusion injury / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 1336-1339, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-478164
Biblioteca responsável:
WPRO
ABSTRACT
RhoA belongs to the small G binding proteins Rho subfamily, playing an important role in the various cellular func-tions, including migration, proliferation, adhesion and apopto-sis. Recent data indicate that RhoA/ROCK pathway causes myo-cardial damage by influencing the myocardial energy metabolism, inflammation, and endoplasmic reticulum stress. On the other hand, the activation of RhoA also has a positive role in MIRI. This article reviews the regulatory effect of RhoA on MIRI and its mechanisms, discusses the prospects of RhoA as a novel thera-peutic target for MIRI, and provides new therapeutic treatments and strategies for MIRI.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2015
Tipo de documento:
Artigo