Association between homocysteine and in-stent restenosis after coronary stenting / 中国介入心脏病学杂志

ABSTRACT

Objective Mounting interest emerged about hyper homocystinemia as an independent risk factor for atherothrombotic disease, and several experimental studies have shown that it may affect in-stent restenosis. The purpose of the present study was to identify the relationship between the serum homocystine level and in-stent restenosis of patients with stable angina after coronary stenting. Methods The study population comprised 168 stable angina patients who underwent stent implantation with drug-eluting stents,including 96 patients without in-stent restenosis ( the control group) and 72 patients with in-stent restenosis(the restenosis group). The level of serum homocystine was measured using the medical inspection center. Coronary angiography was performed immediately before and after stent implantation and 12-18 months later. Resu1ts Baseline characteristics including drug used after PCI were similar between the 2 groups. Serum homocystinelevel in patients of the control group were significantly lower than that in restenosis group [ ( 11. 68 ± 3. 54 )μmol/L vs. ( 18. 54 ± 4. 39 )μmol/L, P = 0. 012 ] . The quantitative coronary angiography (QCA) showed that lesion length was similar between the 2 groups, minimumlumen diameter (MLD) and stenosis rate were also similar before and after stents implantation (all P﹥0. 05). Restenosis rate [(33. 24 ± 12. 52)% vs. (84. 23 ± 13. 26)%,P=0. 000] and late lumen less [(0. 36 ± 0. 21)mm vs. (1. 82 ± 0. 68)mm,P=0. 000] were lower in the control group than in the restenosis group. Conc1usions Higher serum homocystine level might be associated with in-stent restenosis after coronary stenting.