Pharmaceutical Care of a Neonate with Septicemia Based on Population Pharmacokinetics / 医药导报

ABSTRACT

Objective To introduce a pharmaceutical care method based on population pharmacokinetics(PPK)and Bayesian method. Methods A predictive model for individualized vancomycin dosing was established based on the JPKD-Bayesian software and a PPK model according to the intervenous drop infusion of vancomycin in Chinese children.Individualized dosage regimen of vancomycin was devised for a neonate with septicemia caused by methicillin-resistant staphylococcus epidermidis (MRSE)using the predictive model. Results The model prediction error of the trough concentration of vancomycin was 0.8 mg·L-1 ,and the weighted residual(WRES)was 8.7%,and thus the predictive accuracy of the model was satisfactory.The MRSE infection in this patient was effectively controlled following individualized vancomycin dosage regimen according to the model predicted results,and there were no vancomycin-caused adverse reactions. Conclusion Application of advanced pharmaceutical knowledge such as PPK contributes to clinical medication,and it can promote the quality of pharmaceutical care provided by clinical pharmacists.