Clinical efficacy of percutaneous kyphoplasty combined with anti-osteoporosis drugs treatment of vertebral compression fracture with osteoporosis in elderly patients / 中国综合临床

ABSTRACT

Objective To investigate the clinical effect of percutaneous kyphoplasty(PKP) combined with anti-osteoporosis drug treatment of vertebral compression fracture with osteoporosis in elderly patients.Methods Fifty-three cases of elderly patients with thoracolumbar vertebral compression fracture due to osteoporosis were selected as subjects,who were hospitalized in the Central Hospital of Sujiatun District of Shenyang from October 2010 to December 2014.They were randomly divided into the observation group (27 cases) and control group(26 cases).All patients were treated with PKP.The patients in the observation group were given the anti-osteoporosis therapy.Before and after operarion,the visual analogue scale(VAS) score was estimated and Cobb's angle of the vertebrae were measured.Postoperative complications,bone mineral density in the first half year after operation were recorded.Results VAS of treatment and of control group before operation were 7.92± 1.00 and 7.89±0.99,higher than those of one week after operation(2.68± 1.01,2.73 ± ± 1.03).Two groups of treatment and control had no significant difference(P＞0.05),but before and one week after operation had significant difference(P=0.037,0.038).Cobb's angle of treatment and control group were (28.23±6.00) ° and (28.10±5.99) ° before operation,(10.90±2.99) ° and (11.09±3.00) ° one week after operation.Two groups of treatment and control had no significant difference(P＞0.05),but before and one week after operation had significant difference (P =0.027,0.029).The bone mineral density in observation group was (0.79±0.12) g/cm2,higher than that in control group((0.65±0.06) g/cm2,P=0.048) in sixth months after operation.The duration of follow up after operetion were 12 months.Recurrence rate of vertebral compression fracture in control group was 15.4％ (4/26),higher than that in observation group (0 (0/26)),and there was significant difference between two groups (P =0.041).Conclusion PKP combined with anti-osteoporosis treatment of vertebral compression fracture with osteoporosis can quickly relieve vertebral fracture pain and reduce the incidence of new vertebral fractures hair.The treatment with minimally invasive and orthopedic effect is worthy of clinical application.