Formula Optimization of Ropivacaine Hydrochloride Transdermal Gel / 中国药师
China Pharmacist
; (12): 660-664, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-490898
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To optimize the formula of ropivacaine hydrochloride transdermal gel.Methods:
The steady transdermal rate and cumulative transdermal percentage in 24 h of ropivacaine hydrochloride gel were used as the indices, an orthogonal design was applied to select the optimal formula, and Design Expert 8. 0. 5. 0 software was used to analyze the results.Results:
The optimal formula con-tained 2% carbomer, 10% propylene-glycol and 5% Azone. The steady transdermal rate of the optimal formula was 0. 6951 mg·h-1 · cm-2 . The cumulative transdermal percentage in 24 h of the optimal formula was 91. 04%, which was 22. 79% higher than that of ropiva-caine hydrochloride solution with the same concentration. Design Expert 8. 0. 5. 0 software could predict the steady transdermal rate and cumulative transdermal percentage in 24 h of the optimal formula.Conclusion:
The preparation design is reasonable, and the gel has promising properties, which is suitable for skin local application.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacist
Ano de publicação:
2016
Tipo de documento:
Artigo