Expressions ofα-catulin and E-cadherin in tongue squamous cell carcinoma tissue and clinical significance / 吉林大学学报(医学版)

ABSTRACT

Objective To observe the expressions ofα-catulin and E-cadherin in tongue squamous cell carcinoma (TSCC)tissue, and to explore their relationship with the occurrence and development of TSCC.Methods The expressions ofα-catulin and E-cadherin in 55 cases of TSCC tissue and 10 cases of normal tongue tissue were examined by immunohistochemistry SP method. The relationship between the expressions and the clinicopathological characteristics and the relevance of the expressions ofα-catulin and E-cadherin in TSCC tissue were analyzed.Results The positive expression rates ofα-catulin in TSCC tissue and normal tongue tissue were 69.09% and 20.00%,respectively,and there was difference between them (P<0.01).The expression ofα-catulin was correlated to the histological differentiation,clinical stage and lymph node metastases of TSCC (P<0.05).The positive expression rates of E-cadherin in TSCC tissue and normal tongue tissue were 38.18% and 80.00%,respectively, and there was significant difference between them (P< 0.01 ). The expression of E-cadherin was correlated to the clinical stage and lymph node metastases of TSCC (P<0.05 ). There was a negative correlation between the expressions ofα-catulin and E-cadherin in TSCC tissue (r=-0.466,P<0.01). Conclusion The expressions ofα-catulin and E-cadherin may be associated with the occurrence and development of TSCC,and they could be used as the parameters which predict the malignant degree and prognosis of TSCC.