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Methylation of microRNAs in leukemia / 国际儿科学杂志
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-496445
Biblioteca responsável: WPRO
ABSTRACT
The methylation of tumor suppressor microRNAs,also known as tumor suppressor microRNA (TS-miRNA),plays an important role in the occurrence and development of leukemia.Methylation of microRNAs usually lead to aberrant proliferation,apoptosis,invasion and metastasis of tumor.It has been proved that mcthylation is also involved in unregulated oncogene expression and ceil cycle in leukemia.Most of the aberrant methylation can be revered by demethylation reagents.Research on the aberrant methylations and the role in the occurrence and development of leukemia may improve the evaluation criteria of diagnosis and prognosis,which will propose a new treatment perspective.

Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: International Journal of Pediatrics Ano de publicação: 2016 Tipo de documento: Artigo
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: International Journal of Pediatrics Ano de publicação: 2016 Tipo de documento: Artigo
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