A Meta-analysis of the accuracy of interferon-γrelease assays in differentiating intestinal tuberculosis from Crohn's disease in Asia / 中华内科杂志
Chinese Journal of Internal Medicine
; (12): 535-540, 2016.
Article
em Zh
| WPRIM
| ID: wpr-497014
Biblioteca responsável:
WPRO
ABSTRACT
Objective This meta-analysis assessed the value of interferon-γ release assays (IGRAs) in the differential diagnosis of intestinal tuberculosis (ITB) from Crohn's disease (CD).Methods Systematic search without language restriction was conducted in the main computerized databases until June 2015.Studies that have evaluated the performance of IGRAs (QuantiFERON-TB Gold or T-SPOT.TB) in distinguishing ITB from CD were eligible.Main outcome measures included sensitivity and specificity.Area under the curve (AUC) of the summary receiver operating characteristic (sROC) curve was used to evaluate the accuracy of IGRAs.Results Twelve studies (all from Asia) were finally included.The pooled sensitivity and specificity of IGRAs for the differential diagnosis of ITB from CD were 82.8% (95%CI 78.4%-86.6%) and 86.7% (95% CI 83.2%-89.6%) respectively.The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were 6.870 (95% CI 5.345-8.830) and 0.171 (95% CI 0.105-0.279).The diagnostic odds ratio was 44.030 (95% CI 27.964-69.325).And the AUC of sROC was 0.939.Conclusions IGRAs have a high sensitivity and specificity for the diagnosis of ITB,and specificity is consistent from study to study.IGRAs may be considered as a supplementary method in the differential diagnosis of ITB from CD.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Systematic_reviews
Idioma:
Zh
Revista:
Chinese Journal of Internal Medicine
Ano de publicação:
2016
Tipo de documento:
Article