The influence of Alpinia calcarata extract on the serum lipid and leptin levels of rats with hyperlipidemia induced by high-fat diet
Asian Pacific Journal of Tropical Biomedicine
; (12): 1822-1826, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-500519
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To study the effect of ethanolic extract from Alpinia calcarata rhizomes on the serum lipid and leptin levels of rats with hyperlipidemia induced by high-fat diet.Methods:
Male wistar rats were divided into six groups normal, high-fat diet control (HFD) and ethanolic extract of Alpinia calcarata rhizomes (ACRE) (100, 200 and 300 mg/kg; p.o.) was administered to the high fat-diet-induced hyperlipidemic rats for 30 days to evaluate its antihyperlipidemic activity. Atorvastatin (10 mg/kg; p.o.) was used as a standard drug.Results:
The results demonstrated that in HFD-induced hyperlipidemic rat, ACRE reduced rat weight gain, triglyceride (TG), total cholesterol levels (TC), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), total protein (TP) and leptin level (pg/mL).Conclusions:
These encouraging findings suggest that ACRE has excellent pharmacological potential to prevent hyperlipidemia.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Asian Pacific Journal of Tropical Biomedicine
Ano de publicação:
2012
Tipo de documento:
Artigo