Retrospective Analysis of Tenofovir Disoproxil Fumarate in the Treatment of Multi-drug Resistant Chronic Hepatitis B / 中国药房
China Pharmacy
; (12): 3251-3252, 2015.
Article
em Zh
| WPRIM
| ID: wpr-500993
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WPRO
ABSTRACT
OBJECTIVE:To observe the short-term efficacy and ADR of tenofovir disoproxil fumarate(TDF)in the treatment of multi-drug resistant chronic hepatitis B(CHB). METHODS:32 patients with multi-drug resistant CHB were analyzed retrospec-tively,and HBV drug-resistant genes were detected before treatment;there were a number of points to resistance;they were gave TDF orally. The recovery rate of serum alanine aminotransferase(ALT),HBV-DNA conversion rate,lactic acid and renal function were observed before and after treatment. RESULTS:The recovery rate of ALT reached 100% at 3 months,and the conversion rate of HBV-DNA reached 96.88%. The lactic acid levels and renal dysfunction was not found during treatment. CONCLUSIONS:TDF take effect quickly on multi-drug resistant CHB,and no obvious ADR is found.
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WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Ano de publicação:
2015
Tipo de documento:
Article