Activation of PI3K-AKT-mTOR signal pathway in Burkitt lymphoma / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 457-460, 2016.
Article
em Zh
| WPRIM
| ID: wpr-501932
Biblioteca responsável:
WPRO
ABSTRACT
Objective To assess the activation of PI3K-AKT-mTOR signal pathway in Burkitt lymphoma.Methods The phosphorylation levels of AKT,mTOR and RPS6 were detected in the tissue sections by immunohistochemistry in 13 cases of Burkitt lymphomas and 14 cases of reactive hyperplasia of lymph nodes.Results The phosphorylation rates of AKT,mTOR and RPS6 were higher in Burkitt lymphoma than those in reactive hyperplasia of lymph nodes [84.6 %(11/13) vs 64.2 %(9/14),100.0 %(13/13) vs 71.4 % (10/14),100.0 % (13/13) vs 78.6 % (11/14),all P <0.05].Conclusion PI3K-AKT-mTOR pathway is abnormally activated in Burkitt lymphoma.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Leukemia & Lymphoma
Ano de publicação:
2016
Tipo de documento:
Article