Observation of the efficacy of atorvastatin combined with aspirin in the treatment of acute cerebral infarction / 中国基层医药

ABSTRACT

Objective To investigate the clinical efficacy of atorvastatin combined with aspirin in the treatment of acute cerebral infarction.Methods 160 patients with acute cerebral infarction were selected,they were randomly divided into two groups,80 cases in each group.The patients in both two groups used aspirin for treatment,while the observation group used atorvastatin for further treatment.All patients were followed up for 1 year,and the ADL score,the US National Institutes of Health neurological function (NIHSS) score,C-reactive protein (CRP),tumor necrosis factorα(TNF-α) and carotid intima-media thickness (IMT) were compared between the two groups.Results Six months and 12 months later after the treatment,the Barthel index in the observation group [(75.15 ± 6.67)points and (79.94 ± 7.84) points] were higher than those in the control group [(5.79 ± 0.68) points and (4.44 ±0.79) points],the differences were statistically significant (t =6.214,P =0.005;t =6.514,P =0.001).Six months and 12 months later after the treatment,the NIHSS scores in the observation group [(3.55 ± 0.85) points and (2.07 ±0.35) points]were higher than those in the control group[(5.79 ±0.68) points and (4.44 ±0.79) points],the differences were statistically significant(t =6.214,P =0.005;t =6.514,P =0.001).The levels of CRP,TNF-αand IMT of the observation group and the control group after treatment decreased significantly(the observation groupt =18.732,P =0.000;t =15.652,P =0.000;t =3.593,P =0.000;the control groupt =7.324,P =0.000;t =4.211,P =0.000;t =2.495,P =0.035).Moreover,the levels of CRP,TNF-α and IMT of the observation group were lower than those of the control group (t =8.893,P =0.000;t =5.819,P =0.000;t =2.984,P =0.015).Conclusion Atorvastatin combined with aspirin therapy can improve the daily skills and nerve function in patients with acute cerebral infarction.Moreover,it is effective to decrease the levels of CRP,TNF-α,IMT.