Management of Acute Submacular Hemorrhage with Intravitreal Injection of Tenecteplase, Anti-vascular Endothelial Growth Factor and Gas
Korean Journal of Ophthalmology
; : 192-197, 2016.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-50643
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
To evaluate the visual and anatomical outcomes for neovascular age-related macular degeneration with submacular hemorrhage after intravitreal injections of tenecteplase (TNK), anti-vascular endothelial growth factor (VEGF) and expansile gas.METHODS:
This study was a retrospective clinical case series following 25 eyes of 25 patients. All patients received a triple injection using 0.05 mL TNK (50 µg), 0.05 mL anti-VEGF and 0.3 mL of perfluoropropane gas. Retreatment with anti-VEGF was performed as needed. Preoperative and postoperative best-corrected visual acuity and central retinal thickness were analyzed.RESULTS:
The mean logarithm of the minimum angle of resolution of best-corrected visual acuity improved significantly from 1.09 ± 0.77 at baseline to 0.52 ± 0.60 at 12 months (p < 0.001). The mean central retinal thickness also improved significantly from 545 ± 156 at baseline to 266 ± 107 at 12 months (p < 0.001). A visual improvement of 0.3 logarithm of the minimum angle of resolution unit or more was achieved in 15 eyes (60%). During the 12 postoperative months, an average of 4.04 intravitreal anti-VEGF injections was applied.CONCLUSIONS:
A triple injection of TNK, anti-VEGF, and a gas appears to be safe and effective for the treatment of submacular hemorrhage secondary to neovascular age-related macular degeneration.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Hemorragia Retiniana
/
Angiofluoresceinografia
/
Acuidade Visual
/
Doença Aguda
/
Estudos Retrospectivos
/
Seguimentos
/
Resultado do Tratamento
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Ativador de Plasminogênio Tecidual
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Fator A de Crescimento do Endotélio Vascular
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Tomografia de Coerência Óptica
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Idoso
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Ophthalmology
Ano de publicação:
2016
Tipo de documento:
Artigo