Research Progress and Therapeutic Prospect of Angiogenesis Inhibitors in the Microvascular Complication of Diabetic Mellitus / 中山大学学报(医学科学版)

ABSTRACT

Microvascular complications of diabetic mellitus injure entire organs of the body. Diabetic retinopathy,foot ulcer, erectile dysfunction and diabetic nephropathy are the major pathogenesis of blindness,non-traumatic amputation,kidney failure and even death,respectively. Thus,early intervention of microvascular complications is the optimized strategy for improving the quality and prolonging the lifespan. Angiogenesis is the one of most significant pathologic features in microvascular complications of diabetic mellitus.Angiogenesis inhibitors are closely involved in the balance regulation of angiogenesis. Therefore ,this review aims to present the research progress and the therapeutic prospect of angiogenesis inhibitors in the microvascular complication of diabetic mellitus.