Research progress in metabolic targets for cancer therapy / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
; (6): 269-278, 2017.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-510965
Biblioteca responsável:
WPRO
ABSTRACT
Cancer cells can change metabolic pathways, including glycolysis and glutamine metabolism, and produce the raw materials needed for rapid proliferation and survival. Therefore, research on metabolic pathways of cancer cells might help find the targets of cancer therapy. In this review, we outlined the metabolic features of aerobic glycolysis, glutamine metabolism and (tricarboxylic acid) TCA cycle in cancer. We also described metabolic targets for cancer therapy and therapeutic agents for the corresponding targets in these metabolic pathways, and finally discussed some of the challenges related to tumor metabolism as a therapeutic target in cancer therapy.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Pharmacology and Toxicology
Ano de publicação:
2017
Tipo de documento:
Artigo