Clinical effect of Chinese herbal medicine decoction combined with mifepristone in the treatment of uterine fibroids and its influence on sex hormone levels / 中国基层医药

ABSTRACT

Objective To observe the curative effect of Chinese herbal medicine decoction combined with mifepristone in the treatment of uterine fibroids and the effects on hormone levels.Methods 100 patients with uterine fibroids were divided into the treatment group and control group according to random number table, 50 cases in each group.The treatment group was given the liquid form joint mifepristone, the control group was given mifepristone.The two groups were treated for a course of 3 months.The sex hormone levels before and after treatment, the symptoms and signs integral related indicators were compared.The clinical efficacy was evaluated.Results The total effective rate of the treatment group was 84%, which was obviously higher than 66% of the control group (x2=9.88,P<0.05).Compared with before treatment[the control group,LH(57.2±9.6)U/L,E2(17.9±6.9)pmol/L,FSF(32.7±8.5)g/L,P(17.5±5.2)nmol/L;the treatment group,LH(56.7±10.2)U/L,E2(17.3±7.9)pmol/L,FSF(33.5±7.9)g/L,P(18.4±3.2)nmol/L], after treatment the levels of sex hormones in the two groups significantly reduced[the control group,LH(47.5±8.3)U/L,E2(12.5±3.8)pmol/L,FSF(18.3±6.9)g/L,P(14.8±3.2)nmol/L;the treatment group,LH(38.7±8.1)U/L,E2(7.5±4.3)pmol/L,FSF(10.2±5.2)g/L,P(10.5±4.8)nmol/L],the differences were statistically significant(all P<0.05).Conclusion Chinese herbal medicine decoction combined with mifepristone in the treatment of uterine fibroids has good clinical curative effect, by increasing the body's immunity, lowering levels of sex hormones in the body, inhibition of smooth muscle tissue, thus to narrow the myoma, improve clinical symptoms, it is worthy of promoting.