Effect of Yulin Mixture on Ovarian Function in Rats with Kidney-yang Deficiency Ovulatory Dysfunction / 中国药师

ABSTRACT

Objective:To observe the effect of Yulin mixture on ovarian function in rats with kidney-yang deficiency ovulatory dysfunction.Methods:The hydrocortisone-induced ovulation disorder rat models were established,and the rats were divided into the model control group,Yulin mixture group and positive control group (clomiphene citrate group),and the normal control group was set up,and 10 rats were in each group.The general situation of the rats was observed.The wet weight indices of uterus and ovary were measured by an electronic analytical balance.Serum estradiol (E2),progesterone (P),follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured by radioimmunoassay.Ovarian morphology was observed after HE staining.Results:Yulin mixture could improve the general status of ovulation disorder rats,increase the wet weight indices of uterus and ovary (P<0.05) and the levels of serum E2,P,LH and FSH (P<0.01),and improve the pathological state of ovarian morphology.Conclusion:Yulin mixture can improve the levels of serum E2,P,LH and FSH resulting in promoting ovarian development.