Study of event-related potentials on implicit cognitive basis in patients with alcohol dependence / 中华行为医学与脑科学杂志

ABSTRACT

Objective To investigate the event-related potentials( ERPs) characters of implicit cog-nitive basis in patients with alcohol dependence(AD). Methods Implicit association task and ERPs were detected in 30 individuals with alcohol dependence and 30 controls. Results In patients group,it revealed interaction between picture type and attitude words(F(1,29)= 32.08, P=0.003),and RTs to alcohol-related picture-positive words((653.2±42.3)ms and RTs to non-alcohol-related picture-negative words((698.5±38. 1)ms) were faster than those of non-alcohol-related picture-positive words((680.2±40.1)ms) and alcohol-related picture-negative words((713.3±43.3)ms).Additionally,the main effects of picture type and attitude words was significant.RTs to alcohol-related picture were faster than those to non-alcohol-related picture. RTs to alcohol-related picture-positive words in patient group were faster than those of controls((710.0±32.3) ms, P=0.009).In patients group,it revealed interaction between P3 amplitudes for picture type and attitude words.P3 amplitudes to alcohol-related picture-positive words were higher than those of P3 amplitudes to al-cohol-related picture-negative words. Interaction among picture type, attitude words and electrode sites was significant in patient group. Conclusions Patients with alcohol dependence present implicit cognitive basis to alcohol related information,and front,front-central and central are neurophysiological architecture.