Effect of Tanshinone on human polymorphonuclear leucocyte chemokinesis / 中国病理生理杂志

ABSTRACT

The paper studied effect of different doses of Tanshinone on human polymorphonuclear leucocyte chemokinesis by agarose microdroplet assay. The results indicate that more than 10ng/ml Tanshinone inhibites significantly human polymorphonuclear leucocyte chemokinetic response to 10~(-9)M FMLP. This inhibitory effect is probably one of mechanisms of Tanshinone anti-inflammatory activity. The agarose microdroplet assay is a reliable mothod for studying leucocyte chemokinesis in vitro.