Studies on the repair of oleic acid induced acute lung injury and the changes of elastase and ?-glucuronidase activities during injury / 中国病理生理杂志

ABSTRACT

Acute lung injury was produced by injection of oleic acid (0.1 ml/kg) intravenously. Within 1 dey after oleic acid, the protein content, total cell counts, elastase, ?_1-antitrypsin and ?-glucuronidase activities were increased in BALF significantly. Histologic examination showed pulmonary hemorrhage, edema and interstitial infiltration of leukocytcs. 3 days after oleic acid, all above changes diminished. 7 days after injection of oleic acid, the changes both in BALF and histologic feature reached normal. The results suggest that, acute lung injury induced by oleic acid could recover completely in 1 week. The role of elastase and ?_1 -Antitrypsin in lung injury and repair was discussed. The possibility of oleic acid induced injury in other organs was noted as well.