Influence of blood brain barrier permeability by propofol in aged and adult rats / 中华麻醉学杂志

ABSTRACT

Objective To evaluate the influence of propofol on the permeability of the blood brain barrier(BBB) in adult and aged rats.Methods Aged or adult rats were given two doses propofol in 1 hour,respectively.BBB permeability was examined by optical microscopy,electromicroscopy and Evans blue(EB) staining.Results (1)Brain EB staining was not seen in aged or adult groups that at either dose of propofol.(2)In all groups of aged and adult rats,the structure of the blood vessels was normal and lanthanum was not seen outside the blood vessels.(3)There were no significant changes in the central nervous system under microscope or electromicroscope in any groups.Conclusions Propofol at the two doses has no significant effect on BBB permeability or on the central nervous system morphology in aged and adult rats.