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Effect of intraventricular injection of histamine on corticotropin releasing hormone neurons in paraventricular nucleus of hypothalamus / 中国病理生理杂志
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-517043
Biblioteca responsável: WPRO
ABSTRACT

AIM:

To study the effect of intraventricular injection(icv) of histamine(HA) on corticotropin releasing hormone (CRH) neurons activity in paraventricular nucleus (PVN) of hypothalamus.

METHOD:

Fos ontogenic protein immunohistochemistry and double antigen immunohistochemistry method; semiquantitative reverse transcription-polymerase chain reaction(RT-PCR) method were used.

RESULTS:

After intraventricular injection of HA, (1) number of Fos immunnoreactive positive neurons in PVN increased significantly; (2) double labeling experiments showed that there were 31 78%?1 59% of Fos immunoreactive cells in PVN expressed CRH simultaneously; (3) the CRHmRNA level in PVN was increased in a dose-dependent manner.

CONCLUSION:

Central histamine activated CRH neurons in PVN of hypothalamus and increase the expression of CRH gene.

Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Pathophysiology Ano de publicação: 1989 Tipo de documento: Artigo
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Pathophysiology Ano de publicação: 1989 Tipo de documento: Artigo
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