Prognostic Significance of C-erbB-2 in Breast Cancer / 中国医师杂志

ABSTRACT

Objective To analyse the clinical and pathological characteristics of C-erbB-2 expression and observe the prognostic significance of C-erbB-2 in breast cancer.Methods The data of 371 breast cancer patients who were treated in our hospital from April 1995 to April 1997 were enrolled in this study.The relationship between C-erbB-2 and clinicopathological indicators was analyzed,and the influence of C-erbB-2 upon disease-free survival and total survival rates were obsevered.Results The rates of C-erbB-2 expression in young premenopausal patients,and in the tissue with higher histologic grade or ER and PR negative were higher.The C-erbB-2 positive patients survival term obviously short than in the C-erbB-2 negative patients.Conclusion The prognosis of patients with C-erbB-2 positive is worse.