Effects of nitric oxide on postoperative peritoneal adhesion formation: an experimental study / 中国普通外科杂志

ABSTRACT

ObjectiveTo investigate the effect of nitric oxide(NO) in preventing postoperative adhesion formation in rats .MethodsForty rats were randomly assigned to 2 different treatment groups.All animal models of postoperative adhesion formation were made in a standard manner. 0.9% NaCl and L-arginine were administered into intraperitoneal cavity before closure and during 3 consecutive days after surgery. On the 3 rd postoperative day,blood was collected to evaluate NO levels and the inserted abdominal walls were removed to assess pathology in some rats.On the 14 th postoperative day,the remaining rats were sacrificed by ether overdose before relaparotomy,and the extent of adhesion formation were assessed.ResultsMore severe adhesions developed in 0.9% NaCl control group(mean score of adhesions 3.7?0.7) than L-arginine group(mean score of adhesions 0.9?1.1)( P