Management of Ectopic Pregnancy by Intramuscular Injection of High Dose of Methotrexate / 中国医师杂志

ABSTRACT

Objective To explore the optimal indication and safety of managing ectopic pregnancy by intramuscular injection of high dose of methotrexate.Methods The patient with unruptured ectopic pregnancy was injected with 50mg/m 2 of methotrexate, the injection of methotrexate was repeated at the same dose if the level of the ?-subunit of human chorionic gonadotropin continues to rise or maintain at a high level 7 days after the primary injection.Results Of 109 cases,100 the patients with ectopic pregnancy were succeeded by conservative therapy. The total success rate was 91 7%. The success rate was 97 7% in patients with a level of the ?-subunit of human chorionic gonadotropin less than 2 5 nmol/L (the normal value is less than 0 82nmol/L), whereas it was 66 7% in patients with a level of the ?-subunit of human chorionic gonadotropin greater than 2 5nmol/L, the difference was statistically significant (P