Study on the Optimization of Prescription and Preparation of Matrine Liposomes / 中国药房
China Pharmacy
; (12)1991.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-524236
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To optimize the prescription and preparation of matrine liposomes.METHODS:
The liposomes were prepared by the reverse-phase evaporation technique;the envelope efficiency and the diameter of matrine liposomes were taken as criteria,the prescription and preparation of the liposomes were optimized by orthogonal design.RESULTS:
The best prescription consisted of egg phosphatidylcholin(80mg),the oil phase cholesterol(15mg),the water phase phosphate buffer so?lution(pH=7.0)and matrine(30mg);the best preparation technics was as followschloroform(30ml),ultrasonic time was10min rotary evaporating temperature at48℃.The liposomes had homogeneous shape with the particle size at250nm~750nm and the envelope efficiency of matrine liposomes at47.25%.CONCLUSION:
The optimized formulation of martine liposomes is reasonable in prescription,practicable in technics,high in envelope efficiency and perfect in stability.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
1991
Tipo de documento:
Artigo