Determination of Cilostazol in Human Plasma by HPLC / 中国药房
China Pharmacy
; (12)2005.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-525741
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To establish a HPLC method for the determination of cilostazol in human plasma.METHODS:
C18 was the chromatographic column,MeOH-0.03mol/L ammonium acetate (62∶38,V/V)was the mobile phase with a flow rate at 0.8 ml/min and detection wavelength at 257 nm,acetic ether was used as the extraction solvent.RESULTS:
Good linear relationship was achieved when the detection concentration range of cilostazol was 10.0~1 500.0 ng/ml(r=0.9 999),the average recovery rates for the high,medium and low concentrations of cilostazol were 99.82%,97.30%and 97.14%,respectively,both the intra-day and inter-day RSD were lower than 6%.CONCLUSION:
This method is sensitive,accurate,simple and fast,which can be used as the clinical monitoring of blood concentration of cilostazol and its pharmacokinetics study.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2005
Tipo de documento:
Artigo