Effects of acute and chronic morphine dependence and withdrawal on CREB-1 protein expression in rat brain / 中华麻醉学杂志

ABSTRACT

0.05) . The CREB-1 protein expression in cortex and hippocampus was significantly up-regulated while that in nucleus accumbens was significantly down-regulated in chronic morphine dependence and abstinence group (groupⅢandⅣ) as compared with control group. The CREB-1 protein expression in nucleus accumbens in groupⅣwas significantly lower than that in groupⅢ. Conclusion Acute morphine dependence and abstinence do not significantly affect CREB-1 protein expression in the brain. The changes in CREB-1 protein expression are different in different brain regions in chronic morphine dependence and abstinence rats.