Effects of steroid hormone on the expression of cyclic nucleotide-gated channels of olfactory receptor neurons / 中国耳鼻咽喉头颈外科
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-529536
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE To observe the effects of Dexamethasone on the expression of cyclic nucleotide-gated channels (CNG channels) mRNA of olfactory receptor neurons (ORNs) by real-time quantitative reverse transcription-polymerase chain reaction(RT-PCR). METHODS Forty Wistar rats were randomly divided into four groups 24-hours Dexamethasone treated group and its control group; 2-weeks Dexamethasone treated group and its control group. Dexamethasone was injected i.p. (1 mg/kg for 24-hours group, 0.2 mg/d for 2-weeks group). Control group rats were injected with the same volume of normal saline. Real-time quantitative RT-PCR was performed to evaluate mRNA production of CNGA2 subunits. RESULTS In Dexamethasone-injected rats, the up-regulation of CNGA2 mRNA was observed in 2-weeks group(P
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Archives of Otolaryngology-Head and Neck Surgery
Ano de publicação:
2006
Tipo de documento:
Artigo