Preparation and Quality Control of Lornoxicam Gel / 中国药房

ABSTRACT

OBJECTIVE: To prepare lornoxicam chitosan gel and to study its quality control method. METHODS: Lornoxicam chitosan gel was prepared with chitosan as excipient. The content of lornoxicam was determined by HPLC. The stability of the preparation was studied by accelerated test and centrifugation. RESULTS: The prepared gel was well-spread, with linear range at 12.5～125.0?g?mL-1 and average recovery at 100.02%(RSD=1.18%). The indexes of stability all met the standard. CONCLUSION: The preparing technology of lornoxicam chitosan gel is simple, and its quality is stable reliable.