Antiplatelet and Anti-thrombotic Effects of ?-cyclodextrin Inclusion of Dragon's Blood / 昆明医科大学学报
Journal of Kunming Medical University
; (12)2006.
Article
em Zh
| WPRIM
| ID: wpr-529738
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate antithrombotic and antiplatelet effects of Dragon's Blood,?-cyclodextrin inclusion of Dragon's Blood.Methods The methods of injection of adenosin diphosphate(ADP) into mouse tail vein,electrically stimulated arterial thrombosis in rats were used to evaluate the anti-thrombotic effects of Dragon's Blood and?-cyclodextrin inclusion of Dragon's Blood,respectively.Platelet aggregation(PRP or washed platelets) was tested according to Born's method.Results ?CYDB significantly protected against thrombosis caused by ADP on mice,and electrical stimulation on rats.In vitro?-cyclodextrin inclusion of Dragon's Blood inhibited AA,ADP,PAF-induced platelet aggregation.Conclusions The results suggest that compared with Dragon's Blood,?-cyclodextrin inclusion of Dragon's Blood has more potent anti-thrombotic effects on the thrombotic models,its mechanisms may be closely related to the inhibition of anti-platelet aggregation.?-cyclodextrin inclusion of Dragon's Blood can improve the bioavailability of Dragon's Blood.
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1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Journal of Kunming Medical University
Ano de publicação:
2006
Tipo de documento:
Article