NOD proteins and lung diseases / 中国病理生理杂志

ABSTRACT

The nucleotide-binding oligomerization domain(NOD)proteins are recently identified as cytosolic pattern recognition receptors located on innate immune and epithelial cells,and recognize pathogen-associated molecular patterns.The NOD1 and NOD2,the two members of NOD protein family,have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan.Besides,NOD proteins have been established as key regulators of cell death and cytokine production,they also have been shown to participate in the pathogeny of allergic disease such as asthma.This review will focus on the identification and functional characterization of NOD proteins,as well as their role in lung diseases.