Effects of Metformin on Serum Sex Hormone and Leptin in Ovariectormized Female Rats / 中国药房
China Pharmacy
; (12)1991.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-531757
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To study the effects of metformin (MF)on serum sex hormone and leptin contents in ovariectormized female rats.METHODS:
40 SD rats were randomly divided into four groups control group(normal saline 5 mL? kg-1?d-1,NS group),OVX group(normal saline 5 mL?kg-1?d-1),OVX+low and high dosage MF group(135,270 mg? kg-1?d-1,MFlow and MFhigh group),all group were ig drugs for 30 days on end.The serum sex hormone indexes including E2,P,LH,LSH and leptin content were measured with RIA.RESULTS:
Compared with NS group,the serum E2 and P content were significantly lower(P0.05).CONCLUSIONS:
MF can significantly improve sex hormone secretion and lower serum content of LEP in OVX rats.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
1991
Tipo de documento:
Artigo