Preparation and Quality Evaluation of Clarithromycin Microcapsules / 中国药房
China Pharmacy
; (12)2005.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-532242
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To prepare and evaluate the quality of clarithromycin microcapsules.METHODS:
Clarithromycin microcapsules were prepared by emulsion-solvent volatilixation method using ethylcellulose as capsule wall material.The particle size,entrapment efficiency,the loading amount and the drug release property in vitro were investigated.RESULTS:
The prepared microcapsules were well-distributed in particle size with average particle size at 33.0~38.0 ?m,encapsulation efficiency at above 87%,loading amount above 45%,and accumulative drug release rate of 75% at 6 h.CONCLUSION:
The method is simple and feasible and the quality of prepared microcapsules is up to the standard.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2005
Tipo de documento:
Artigo