Effects of Tanreqing Injection on Immune Factors and Clinical Outcome in Patients with Ventilator Associated Pneumonia / 中国药房

ABSTRACT

OBJECTIVE:To observe the effects of Tanreqing injection on the immune factors and clinical outcome in patients with ventilator associated pneumonia(VAP).METHODS:155 patients with VAP were randomly divided into trial group and control group.Serum levels of CRP,IL-6 and TNF-? were determined at 0,1,3,5 and 7 days after treatment.The chest X-ray results at 0 and 3 days after treatment were compared.The mechanical ventilation(MV)time and the successful rate of weaning from mechanical ventilation and the mortality rate were recorded.RESULTS:The serum levels of CRP,IL-6 and TNF-? in all 155 VAP patients were significantly higher than normal levels,at 5 days,serum levels of IL-6 and TNF-? in the trial group began to decrease significantly as compared with the control group(P