Preparation of Huperzine A Double-layer Sustained Release Tablets and Their in Vitro Release Characteristics / 中国药房
China Pharmacy
; (12)2005.
Article
em Zh
| WPRIM
| ID: wpr-532580
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: To study the preparation of Huperzine-A double-layer sustained release tablets and their in vitro release characteristics.METHODS: With HPMC K4M as matrix and lactose as diluting agent for the sustained release layer,and with starch-calcium carbonate as diluting agent and sodium carboxymethyl starch as disintegrating agent for the fast release layer to prepare the double-layer tablets by compression,with the release rate of the compressed tablets determined by HPLC.RESULTS: The fast release layer of the prepared Huperzine-A double-layer tablets disintegrated within 1~2 min and appeared as fine powder,meeting the requirement;the release curve of the sustained release layer of the tablets was in line with Higuchi equation and maintained a sustained release of 12 hours.CONCLUSION: The prepared Huperzine-A double-layer tables achieved the goal of both immediate release and sustained release.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Ano de publicação:
2005
Tipo de documento:
Article