Derma Safety of Miconazole and Chloramphenicol Cream for Guinea Pigs / 中国药房
China Pharmacy
; (12)2005.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-532673
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To evaluate the derma safety of miconazole and chloramphenicol cream (MCC) for Guinea pigs.METHODS:
Blank matrix,positive sensitizing agent (2,4-dinitro-chlorobenzene) and MCC (high dose and low dose) were applied on normal or damaged areas of the unhairing backs of Guinea pigs to conduct acute toxicity test,sensitivity test and irritation test,respectively.RESULTS:
MCC caused no acute toxicity when applied on the skin of Guinea pigs,nor skin/systemic hypersensitive reaction was noted after repeated sensitization.Single or multiple dosing of MCC caused no irritation on normal skin of Guinea pigs but caused mild irritation on damaged skin which disappeared after 48 h or 72 h.CONCLUSION:
MCC has good dermo safety for Guinea pigs.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2005
Tipo de documento:
Artigo