Determination of the Entrapment Efficiency of Tetracaine Hydrochloride Liposome by the Microcolumn Centrifugation-HPLC / 中国药房
China Pharmacy
; (12)2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-532946
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To develop a method for determining the entrapment efficiency of tetracaine hydrochloride liposome.METHODS:
The microcolumn centrifugation was adopted to separate the free tetracaine hydrochloride from liposomes;the content of tetracaine hydrochloride was determined by HPLC and the entrapment efficiency was computed.RESULTS:
By microcolumn centrifugation,the liposomes and the free tetracaine hydrochloride were well-separated.The recovery rate of the blank liposomes was 90.4%~100.1%;the absorption rate of free tetracaine hydrochloride was 96.6%~99.2%;and the entrapment efficiencies of tetracaine liposomes stood at about 80%.CONCLUSION:
This method established for determining the entrapment efficiency of tetracaine hydrochloride liposome is simple,rapid and reproducible.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2007
Tipo de documento:
Artigo