Study on Preparation of Temperature Sensitive Hydrogel of Chitosan/Polyvinyl Alcohol/Sodium Glycerophosphate and Its Characteristics / 中国药房
China Pharmacy
; (12)1991.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-533312
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To prepare temperature sensitive hydrogel which is of strength.METHODS:
The hygrogel was prepared using CS,PVA and GP as matrix with concentration of CS(A),weight ratio of CS to PVA(B) and pH value(C) as factors and with initial gelatination temperature,strength and dehydration as indexes.The formula was optimized by orthogonal experiment and verified.RESULTS:
The optimal formula was as followsA 20 mg?mL-1,B 11,C 7.2.The prepared hydrogel was fluid at 4 ℃ or room temperature while gelatinized at 37 ℃ within 10 min with strength of about 1.4 kPa.Gelatination time reduced along with the increase of temperature.The pH value had hardly changed during degradation in vitro within 28 d.CONCLUSION:
The CS/PVA/GP hydrogel is simple and practical in preparation technique and is temperature sensitive and of strength.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
1991
Tipo de documento:
Artigo