Improvement of the Formula and Preparation Technology of Metronidazole Cream / 中国药房

ABSTRACT

OBJECTIVE: To improve the quality of metronidazole cream. METHODS: The composition of matrix of metroni-dazole cream was adjusted to improve the formula and the way to adding principal composition was improved to promote the preparation technology. The preparation prepared by improved formula and primary formula were sampled for one-year sample observation test. RESULTS: The preparation prepared by improved formula was characterized with delicate and no grit perception. It did not become hard or dry. Its stability was significantly superior to the preparation prepared by primary formula. CONCLUSION: The formula of metronidazole cream is reasonable and preparation technology is simple, practical, controllable and reliable in quality.